

Methoxy-poly(ethylene glycol)20K-block-poly(D-lysine hydrochloride) is a linear hydrophilic block copolymer which has a poly(D-lysine hydrochloride) section and a non-reactive PEG20K section. It is a crystalline solid soluble in water. Upon derivatization of the poly(D-lysine hydrochloride) part, it can self-assemble into particles in aqueous solution with a hydrophobic poly(D-lysine) core and a hydrophilic PEG shell.