Image: 
Polysarcosine-N-acetamide Structure
Polysarcosine-N-acetamide GPC Chromatogram

Polysarcosine is a polypeptoid made of the endogenous sarcosine amino acid (N-methylated glycine). It has PEG-like physicochemical properties such as water solubility and no reported cytotoxicity and immunogenicity. Lately, it is considered as a potential alternative to PEG in many bioapplications.

This particular polysarcosine has a non-reactive alkylamide function on the C-terminal and a non-reactive acetyl function on the N-terminal.

Image: 
Methoxy-poly(ethylene glycol)-block-poly(D,L-glutamic acid sodium salt) Structure

Methoxy-poly(ethylene glycol)-block-poly(D,L-glutamic acid sodium salt) is a linear hydrophilic block copolymer which has a poly(D,L-glutamic acid sodium salt) section and a non-reactive PEG section. It is a crystalline solid soluble in water. Upon derivatization of the poly(D,L-glutamic acid sodium salt) part, it can self-assemble into particles in aqueous solution with a hydrophobic poly(D,L-glutamic acid) core and a hydrophilic PEG shell.

Pages